I have weird or controversial reactions to most medications, especially psychiatric and drugs. I have no clue why. I have MS, I have brain lesions, they might p

I have weird or controversial reactions to most medications, especially psychiatric and drugs. I have no clue why. I have MS, I have brain lesions, they might play a part. - For example nothing happened from 190 x 1 mg alprazolam + 0.5 L whiskey. - None of the psychiatric medications worked for me (tried almost all there is, it took a long time). No pros, nor cons. - Opiates do not cause euphoria, nor sedation for me. Without tolerance. - The list goes on... I have never figured out why medications affect me extremely differently from other people. I took 5 x 50 mg DPH, nothing happened, then the next day I took it again, and I got anticholinergic toxicity. Perhaps it accumulated in this case, but yeah, it was one of the worst experiences I have had (delirium with dysphoric hallucinations, cognitive decline, memory issues). Took me months to recover. I have had auditory hallucinations for a couple of days, too. What cholinergics and anticholinergics have you tried and what were your experiences?