25 ms·

It could be the biggest drug. It might get out of phase 3. It may get approval very soon. And of course, "may be a game changer." When the news is this fas

It could be the biggest drug. It might get out of phase 3. It may get approval very soon. And of course, "may be a game changer." When the news is this fast and loose with anything that even looks like a fact how am I not to see this as rank manipulation? There is nothing critical in this article except for how hard doctors and insurance companies might be pressed to prescribe it. Then they end with this gem: "But Seigerman said it will also put pressure on smaller companies developing pills, such as Structure Therapeutics, to find a partner that can help them compete in the weight loss drug market with pharmaceutical behemoths like Eli Lilly. " Oh. I see. It's not just manipulation but dumb protectionist gate keeping. Depressing.

RedditKon 2y ago
Phase 2 clinical trials showed 14.7% mean weight reduction at 36 weeks in adults. That's pretty substantial. Obviously no one knows what Phase 3 will show, but cynicism seems unwarranted at this point. https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-results-published-new-england-journal-medicine https://investor.lilly.com/news-releases/news-release-detail...
- timewizard 2y ago
  [flagged]
  - derektank 2y ago
    I don't understand what your criticism is here exactly. Of course Eli Lilly will release a press release if the results of a clinical trial are good but that doesn't make the underlying research (published in the Lancet [1]) suspect in any way. Clinical trials are overseen by the FDA and frequently conducted by third party research scientists without a financial stake in the long term success of the intervention being studied. In this case, it appears that the study authors were researchers at Velocity Clinical Research and they found significant body weight loss with side effects comparable with other GLP-1 agonists. Skepticism might be warranted, particularly until phase 3 trials are conducted, but mindless cynicism hardly seems warranted. [1] https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01302-8/abstract https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
    - timewizard 2y ago
      [flagged]

RedditKon 2y ago

Phase 2 clinical trials showed 14.7% mean weight reduction at 36 weeks in adults. That's pretty substantial. Obviously no one knows what Phase 3 will show, but cynicism seems unwarranted at this point. https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-results-published-new-england-journal-medicine https://investor.lilly.com/news-releases/news-release-detail...

timewizard 2y ago
[flagged]
- derektank 2y ago
  I don't understand what your criticism is here exactly. Of course Eli Lilly will release a press release if the results of a clinical trial are good but that doesn't make the underlying research (published in the Lancet [1]) suspect in any way. Clinical trials are overseen by the FDA and frequently conducted by third party research scientists without a financial stake in the long term success of the intervention being studied. In this case, it appears that the study authors were researchers at Velocity Clinical Research and they found significant body weight loss with side effects comparable with other GLP-1 agonists. Skepticism might be warranted, particularly until phase 3 trials are conducted, but mindless cynicism hardly seems warranted. [1] https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01302-8/abstract https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
  - timewizard 2y ago
    [flagged]