4 ms·

> Double blind randomized controled trial or it didn't happen. This is just cargo culting. Read the original source paper and you'll understand why the causal

• gus_massa 2y ago
  Do you have the DOIs? I found https://www.nature.com/articles/s41591-024-03201-5 https://www.nature.com/articles/s41591-024-03201-5 They compare people that got the old vaccines in 2014-2017 with people that got the new vaccine in 2018-2020. Some strange parts: They say they are analyzing 6 years, but for the second group the 6 years period has not ended. This makes the comparison difficult. These periods includes the covid-19 epidemic in 2020, with lock downs, changes in death rates and new vaccines. This makes any comparison difficult. The comparison in figure "1 e" have very different initial slopes. I'd expect dementia to be a slow accumulation of small problems in the brain, so I'd expect an initial equal slope and after some time a difference. They start the comparison after 3 month, but I expect a slower effect. Figure "1 f" has the same initial slope difference, but there is also a strange slope change in d=1750 and the red line is more noisy probably due to the unfinished 6 years period).
  • kps 2y ago
    Preprint of the main paper on pubmed: https://pmc.ncbi.nlm.nih.gov/articles/PMC10246135/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10246135/ They rule out the objections in your top post — as well as whether people chose to get the vaccine, which would be a huge confounder for a disease that affects cognition.
    • gus_massa 2y ago
      In your link, they also cut at 2020 that is very difficult to compensate in a comparison.