> The possibility that what we now label as “symptoms” might have once been adaptive features For me, this "but what if there was an upside" question has often

> The possibility that what we now label as “symptoms” might have once been adaptive features For me, this "but what if there was an upside" question has often popped up in different biological contexts, ever since learning that the sickle-cell mutation (one copy, for reduced negatives) confers resistance to malarial infection.