Ken Kesey's "One Flew Over the Cuckoo's Nest" was a groundbreaking novel and wouldn't have been so if it weren't for LSD. Of Course, that was Kesey's first and

Ken Kesey's "One Flew Over the Cuckoo's Nest" was a groundbreaking novel and wouldn't have been so if it weren't for LSD. Of Course, that was Kesey's first and only criticaly acclaimed novel and he has said later in life that too much acid screwed him up, I certainly wouldn't argue it's sustainable over a career. LSD also changed pop music in a pretty major way.