> The biggest issue is that fructose doesn't tell the brain that you've had enough, while glucose does (I'm guessing it's because of the delay the liver adds.)

> The biggest issue is that fructose doesn't tell the brain that you've had enough, while glucose does (I'm guessing it's because of the delay the liver adds.) So you can eat more fructose than glucose without starting to feel weird. At the same time, you're straining the liver. This might be the money shot. Basically, HFCS isn't much worse in of itself, but humans are much more prone to overconsume products with high amount of sucrose. Thanks for making the point!