From what I learned 15 years ago, but am too lazy to fact check now... Fructose is metabolized in the liver, i.e. similar to alcohol. Glucose can be used direc

From what I learned 15 years ago, but am too lazy to fact check now... Fructose is metabolized in the liver, i.e. similar to alcohol. Glucose can be used directly by cells. The biggest issue is that fructose doesn't tell the brain that you've had enough, while glucose does (I'm guessing it's because of the delay the liver adds.) So you can eat more fructose than glucose without starting to feel weird. At the same time, you're straining the liver. If you're eating equal parts glucose and fructose (like sucrose), it's not a problem, as your body is used to it and can adjust its glucose sensitivity. But if you completely remove that signal substance, it doesn't stand a chance.