2 ms·
Maybe you mean B6, which is associated with small fiber neuropathy. B12 has to jump through a number of hoops before it‘s even converted into a usable form [1]
by manmal 2y ago
Maybe you mean B6, which is associated with small fiber neuropathy.
B12 has to jump through a number of hoops before it‘s even converted into a usable form [1].
I‘m sure you‘re meaning well, but B12 deficiency is a wide spread problem [2], and it’s questionable that excess is worse than deficiency.
1: https://pubmed.ncbi.nlm.nih.gov/19832808/#&gid=article-figures&pid=figure-1-uid-0 https://pubmed.ncbi.nlm.nih.gov/19832808/#&gid=article-figur...
2: https://pmc.ncbi.nlm.nih.gov/articles/PMC7792587/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7792587/
EDIT: After posting, I saw your other comments. Maybe you can update parent.
- Jarmsy 2y agoAnd one reason for taking B12 is actually to prevent neuropathy.
- manmal 2y agoLooking at the interactions in metabolism, I don’t see it. A low B6 diet and focus on conversion to P5P and oxidation of the excess (Aldehyde Oxidase, and maybe by proxy the ALDHs) is a safer bet.
- Jarmsy 2y agohttps://www.foundationforpn.org/causes/nutritional-and-vitamin-deficiency-neuropathy/ https://www.foundationforpn.org/causes/nutritional-and-vitam... https://pmc.ncbi.nlm.nih.gov/articles/PMC9704859/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9704859/ https://onlinelibrary.wiley.com/doi/10.1111/ene.14786 https://onlinelibrary.wiley.com/doi/10.1111/ene.14786