We know that rapid weight loss causes muscle loss at a higher rate than slower weight loss in general. GLP-1s might enhance this effect somewhat, but there is

We know that rapid weight loss causes muscle loss at a higher rate than slower weight loss in general. GLP-1s might enhance this effect somewhat, but there is nothing definitive. Adequate protein intake + resistance training can fully counteract it, however. I've even added significant lean body mass while losing fat while on GLP-1s.