4 ms·

Yeah, I just went down a rabbit hole re-looking this up myself. It seems that there's nothing unique about semaglutide, and %FFM loss is just a function of how

Yeah, I just went down a rabbit hole re-looking this up myself. It seems that there's nothing unique about semaglutide, and %FFM loss is just a function of how rapidly you lose weight. The most rapid losers on semaglutide have the same %FFM loss (30%) as bariatric patients, for example. And if you don't want to lose weight that fast, you can just temper the dose (unlike with bariatric surgery).

s1artibartfast 2y ago
Or eat protein and exercise. I think it's extremely probable that the most rapid losers are running the largest calorie deficit and also the largest protein deficit.
- borgdefenser 2y ago
  There is an age/hormone variable too. I would have said just eat protein and work out when I was in my teens, 20s and early 30s too. I am 48 and not on testosterone, yet. I actually can't recover at this point from workouts that burn enough calories vs working out less but more calorie restriction in terms of fat loss. Even 60 minute walks cause me to be more hungry to be able to recover from than what I can restrict without walking. I am at the final death throws of natural and not being on TRT basically. I have been pushing TRT out since my late 30s but have gone way too far. I think the TRT threshold probably be when you can't outrun calorie restriction by working out. For me, that has probably been since 43 or 44. By 46 for sure. Personally, I don't need GLP-1s. So many people though do.
borgdefenser 2y ago
Keep in mind I am not using GLP-1s myself because I am unsure of the long term risks. What worries me is if what if in 20 years of use, something with insulin gets blown out? There is a chance it could be a drug for life like testosterone. We know though how devastating obesity is on health so it is really going to be up to the individual to take the risk. Not really my business at that level.

s1artibartfast 2y ago

Or eat protein and exercise. I think it's extremely probable that the most rapid losers are running the largest calorie deficit and also the largest protein deficit.

borgdefenser 2y ago
There is an age/hormone variable too. I would have said just eat protein and work out when I was in my teens, 20s and early 30s too. I am 48 and not on testosterone, yet. I actually can't recover at this point from workouts that burn enough calories vs working out less but more calorie restriction in terms of fat loss. Even 60 minute walks cause me to be more hungry to be able to recover from than what I can restrict without walking. I am at the final death throws of natural and not being on TRT basically. I have been pushing TRT out since my late 30s but have gone way too far. I think the TRT threshold probably be when you can't outrun calorie restriction by working out. For me, that has probably been since 43 or 44. By 46 for sure. Personally, I don't need GLP-1s. So many people though do.

borgdefenser 2y ago

Keep in mind I am not using GLP-1s myself because I am unsure of the long term risks. What worries me is if what if in 20 years of use, something with insulin gets blown out? There is a chance it could be a drug for life like testosterone. We know though how devastating obesity is on health so it is really going to be up to the individual to take the risk. Not really my business at that level.