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Awesome, I appreciate that. Ok so my question for the researcher would be: 1. Circumstances where both mtDNA and Y chromosome are shared between biological fat
by ttyprintk 2y ago
Awesome, I appreciate that. Ok so my question for the researcher would be:
1. Circumstances where both mtDNA and Y chromosome are shared between biological father and pedigreed father. I think the Biblical term is Levirate marriage.
2. Circumstances without Y where maternity is secretly disputable and paternity uncontentious. I think the researcher called this secret adoption.
At distances longer than several generations, is there noise in the measure of autosomal matches such that you cannot detect these?
- tetris11 2y agoI'd argue that after 5 generations your descendants only have (0.5^5) no more than 3% of your genetic material, and if there's some ambiguity to one of your founders (say who has a 50% similarity to the one stated in the pedigree) then that drops to 1% (rounding down). 1% of the human genome (3billion bp) is still 30M bases, which could easily contain 1 or 2 genes which you may have genotyped, depending on the resolution of your genotyping chip (usually 10M markers spread out over the entire genome, and usually clustered around variants/genes of interest). So yeah, even 5 generations down these differences could be detected at the variant level. Even at 10, you could still _theoretically_ find differences. I stress theoretically, because the chance of you having all the individuals from a pedigree genotyped at the same time using the same tech (and thus the same subset of common genotypes to compare) is slim to none. I'd say 5 generations is a rough rule of thumb where the signal is not that much higher than the noise.