3 ms·

> I'm sure some of his advice has backing to it. A lot of it doesn't. A good amount of it even has a fair body of evidence against the claim (like Alzheimer's c

> I'm sure some of his advice has backing to it. A lot of it doesn't. A good amount of it even has a fair body of evidence against the claim (like Alzheimer's can be stopped by using tobacco). Can you post the quote/reference for this? At worst I would think he referenced some observational study about smokers - people ingesting significant nicotine - having lowered incidences of Alzheimer's. That wouldn't surprise me in the slightest because we see the same types of studies for things like caffeine. Mild stimulants and metabolism boosters in particular (energy and metabolism are the core of Peat's theories) are likely associated with protective effects. So please post specifics from Peat, and be careful to avoid internet broken telephone - a lot of people attribute quotes and ideas to him that he never said nor endorsed.

cogman10 2y ago
Devil of a time digging up the original source, but here it is. > People who take aspirin, drink coffee, and use tobacco, have a much lower incidence of Alzheimer’s disease than people who don’t use those things. Caffeine inhibits brain phospholipase, making it neuroprotective in a wide spectrum of conditions. In recent tests, aspirin has been found to prevent the misfolding of the prion protein, and even to reverse the misfolded beta sheet conformation, restoring it to the harmless normal conformation. Nicotine might have a similar effect, preventing deposition of amyloid fibrils and disrupting those already formed (Ono, et al., 2002). Vitamin E, aspirin, progesterone, and nicotine also inhibit phospholipase, which contributes to their antiinflammatory action. Each of the amyloid-forming proteins probably has molecules that interfere with its toxic accumulation. https://raypeat.com/articles/aging/madcow.shtml https://raypeat.com/articles/aging/madcow.shtml

cogman10 2y ago

Devil of a time digging up the original source, but here it is. > People who take aspirin, drink coffee, and use tobacco, have a much lower incidence of Alzheimer’s disease than people who don’t use those things. Caffeine inhibits brain phospholipase, making it neuroprotective in a wide spectrum of conditions. In recent tests, aspirin has been found to prevent the misfolding of the prion protein, and even to reverse the misfolded beta sheet conformation, restoring it to the harmless normal conformation. Nicotine might have a similar effect, preventing deposition of amyloid fibrils and disrupting those already formed (Ono, et al., 2002). Vitamin E, aspirin, progesterone, and nicotine also inhibit phospholipase, which contributes to their antiinflammatory action. Each of the amyloid-forming proteins probably has molecules that interfere with its toxic accumulation. https://raypeat.com/articles/aging/madcow.shtml https://raypeat.com/articles/aging/madcow.shtml