It's hard to say because it depends on population genetics and demographic patterns which vary widely over time period and culture, but it's probably in the bal

It's hard to say because it depends on population genetics and demographic patterns which vary widely over time period and culture, but it's probably in the ballpark of a hundred million or more in the totality of human existence. I'm on my phone and can't access my notes so I'm going from memory but if we are to take the hemolytic fatality rate in Sub-Saharan Africa as the upper limit, it's on the order of 0.1% of all births. Given the general estimate of 100-120 billion humans who have ever lived, the numbers are staggering.