Luteolin itself doesn't require cofactors as it is not enzymatic and the human body does not produce it. To humans, it's simply an exogenous small molecule...

Luteolin itself doesn't require cofactors as it is not enzymatic and the human body does not produce it. To humans, it's simply an exogenous small molecule... Like, e.g., aspirin. S-adenosylmethionine is presumably involved in its metabolism and excretion. This doesn't imply that you'd want to take SAMe with your luteolin dose.