3 ms·

A rebranding to a non-prescription drug will depend on how the prevalence × severity of side effects [0] turns out longer-term. I hope that you are right, but i

by layer8 2y ago

A rebranding to a non-prescription drug will depend on how the prevalence × severity of side effects [0] turns out longer-term. I hope that you are right, but it seems too early to tell. [0] https://www.sciencedirect.com/science/article/pii/S2667368124000299 https://www.sciencedirect.com/science/article/pii/S266736812... https://www.gov.uk/drug-safety-update/glp-1-receptor-agonists-reminder-of-the-potential-side-effects-and-to-be-aware-of-the-potential-for-misuse#risk-of-adverse-drug-reactions-associated-with-glp-1ra-medicines https://www.gov.uk/drug-safety-update/glp-1-receptor-agonist...

SoftTalker 2y ago
"Gastrointestinal side effects" I assume that is code for excessive and frequent evacuation of watery feces.
- layer8 2y ago
  “common gastrointestinal side-effects of GLP-1RAs treatment (including nausea, vomiting, diarrhoea and constipation) can persist for several days and may affect more than 1 in 10 patients”
  - op00to 2y ago
    For me, nausea only appears when I eat poorly - poor quality, or more than I should. Also increasing a dose can cause a bit of nausea for a few hours.
- gwbrooks 2y ago
  People seem to handle it very differently, according to my doc. I never had issues while taking Mounjaro or Synjardy (a prescription pill for diabetes management with similar side effects) alone, but the two together meant I could count on a couple of bad days a week. Sidebar: Mounjaro changed my life. I'd been very diabetic (300 units of insulin a day) for years on end. Taking that much insulin, my normally large frame got very large indeed. A couple of months into the Mounjaro and I was off insulin; a year into it and I was down 75 lbs and healthier than I'd been in 20 years.
- deleted 2y ago
  [deleted]
- op00to 2y ago
  It’s actually the opposite. GLP-1s slow down the digestive tract, so my shits are far more well formed than before. This isn’t like olestra, where excess fat caused diarrhea.
  - galangalalgol 2y ago
    Ok I'd been considering it already, but now I'm sold. I have the transit time of a canid.
    - op00to 2y ago
      It’s wild. I’ve never experienced burping food and tasting what I ate earlier, food just kinda rolls right through. Now, I get to really enjoy it a second time.
      - iheartblocks 2y ago
        Who needs an appetite suppressant when they have comments like these?
        op00to 2y ago
        Let me know when you need a little appetite adjustment. Free of charge!
    - phil21 2y ago
      fwiw tirzepatide (likely the GIP component) cleared up my lifelong IBS within days of my first dose. I consider it a likely lifelong medication now simply due to that night and day difference to my life. It’s extremely rare I have a day where I need to be within 5 minutes of a restroom now. My primary care doctor mentioned this might be a side effect when I first started, and she ended up being more correct than even she expected to be.

by layer8 2y ago

SoftTalker 2y ago

"Gastrointestinal side effects" I assume that is code for excessive and frequent evacuation of watery feces.

layer8 2y ago
“common gastrointestinal side-effects of GLP-1RAs treatment (including nausea, vomiting, diarrhoea and constipation) can persist for several days and may affect more than 1 in 10 patients”
- op00to 2y ago
  For me, nausea only appears when I eat poorly - poor quality, or more than I should. Also increasing a dose can cause a bit of nausea for a few hours.
gwbrooks 2y ago
People seem to handle it very differently, according to my doc. I never had issues while taking Mounjaro or Synjardy (a prescription pill for diabetes management with similar side effects) alone, but the two together meant I could count on a couple of bad days a week. Sidebar: Mounjaro changed my life. I'd been very diabetic (300 units of insulin a day) for years on end. Taking that much insulin, my normally large frame got very large indeed. A couple of months into the Mounjaro and I was off insulin; a year into it and I was down 75 lbs and healthier than I'd been in 20 years.
deleted 2y ago
[deleted]
op00to 2y ago
It’s actually the opposite. GLP-1s slow down the digestive tract, so my shits are far more well formed than before. This isn’t like olestra, where excess fat caused diarrhea.
- galangalalgol 2y ago
  Ok I'd been considering it already, but now I'm sold. I have the transit time of a canid.
  - op00to 2y ago
    It’s wild. I’ve never experienced burping food and tasting what I ate earlier, food just kinda rolls right through. Now, I get to really enjoy it a second time.
    - iheartblocks 2y ago
      Who needs an appetite suppressant when they have comments like these?
      - op00to 2y ago
        Let me know when you need a little appetite adjustment. Free of charge!
  - phil21 2y ago
    fwiw tirzepatide (likely the GIP component) cleared up my lifelong IBS within days of my first dose. I consider it a likely lifelong medication now simply due to that night and day difference to my life. It’s extremely rare I have a day where I need to be within 5 minutes of a restroom now. My primary care doctor mentioned this might be a side effect when I first started, and she ended up being more correct than even she expected to be.