> Not outperforming a placebo means they don't actually do anything. SSRIs are potent pharmaceutical drugs that have multiple, very strong effects. For exampl

> Not outperforming a placebo means they don't actually do anything. SSRIs are potent pharmaceutical drugs that have multiple, very strong effects. For example, Setraline (SSRI) is one of the most effective drugs to treat premature ejaculation. It used to be prescribed for exactly this purpose (and maybe still is). If anything, this is one of the most pronounced and easily measurable effects of SSRIs. If I took 25mg of setraline per day (extremely small dose) for a week, it would become impossible to ejaculate. It also has a whole multitude of other effects that are more dependent on individual (age, gender, bodyweight, etc), some other effects for males are -> crushing testosterone levels, weakness. For me personally, it turns me extremely, extremely emotional, makes me able to sleep all the time, and mentally turns you into a zombie where your lifes dreams and aspirations just disappear. Does it help with depression? I would say no. That however doesn't mean it doesn't do anyting, because they do all sorts of things. It is a very potent and poorly understood pharmaceutical.