4 ms·

What does this even mean? The results of GLP-1 meds are well studied and widely understood to be game changing and likely revolutionary. The other claims might

What does this even mean? The results of GLP-1 meds are well studied and widely understood to be game changing and likely revolutionary. The other claims might be hyperbolic but results of the medication on individuals is not really a question at this point.

mordymoop 2y ago
People are weirdly resistant to acknowledging the obvious implications of things if those implications seem big. There’s a broad “nothing ever happens” heuristic that people tend to mistake for wisdom.
danjl 2y ago
The short term results are known, but we have very little data about the long term effects as of yet.
- TaupeRanger 2y ago
  Not remotely true. We have strong studies out to 10 years at this point. Given the overwhelmingly positive results at our current state, it would take a huge safety signal occurring at 12-20+ years of usage to provoke a change in recommendation, and this is exceedingly unlikely. Basically all such signals are revealed by 10 years if they exist.
fourside 2y ago
I think some skepticism is warranted. If this is a medication that most of us can be on and it comes with positive health benefits, that would mean that humans as a species have lower than optimal GLP-1 levels. I guess it’s possible that our bodies are wired for a world that is unlike today’s and that these drugs correct for that. But drugs that doesn’t come with side effects. It also wouldn’t be the first time that a drug company manages to convince the medical community to think a drug is healthier than it really is (OxyContin).
- resoluteteeth 2y ago
  > I guess it’s possible that our bodies are wired for a world that is unlike today’s and that these drugs correct for that. The constant access to unlimited tasty food we have now is completely unprecedented in human history. Other animals will also overeat if you give them unlimited access to tasty high calorie food. This is absolutely a situation we did not evolve to be able to handle unfortunately. Lack of sufficient food was the norm for most of our history, so it's not surprising that we evolved to want to eat a calorie surplus if possible.

mordymoop 2y ago

People are weirdly resistant to acknowledging the obvious implications of things if those implications seem big. There’s a broad “nothing ever happens” heuristic that people tend to mistake for wisdom.

danjl 2y ago

The short term results are known, but we have very little data about the long term effects as of yet.

TaupeRanger 2y ago
Not remotely true. We have strong studies out to 10 years at this point. Given the overwhelmingly positive results at our current state, it would take a huge safety signal occurring at 12-20+ years of usage to provoke a change in recommendation, and this is exceedingly unlikely. Basically all such signals are revealed by 10 years if they exist.

fourside 2y ago

I think some skepticism is warranted. If this is a medication that most of us can be on and it comes with positive health benefits, that would mean that humans as a species have lower than optimal GLP-1 levels. I guess it’s possible that our bodies are wired for a world that is unlike today’s and that these drugs correct for that. But drugs that doesn’t come with side effects. It also wouldn’t be the first time that a drug company manages to convince the medical community to think a drug is healthier than it really is (OxyContin).

resoluteteeth 2y ago
> I guess it’s possible that our bodies are wired for a world that is unlike today’s and that these drugs correct for that. The constant access to unlimited tasty food we have now is completely unprecedented in human history. Other animals will also overeat if you give them unlimited access to tasty high calorie food. This is absolutely a situation we did not evolve to be able to handle unfortunately. Lack of sufficient food was the norm for most of our history, so it's not surprising that we evolved to want to eat a calorie surplus if possible.