All of this fine, but surely in your context the efficacy of SSRIs should not imply the accuracy of a serotonin theory of depression. At best we know that the m

All of this fine, but surely in your context the efficacy of SSRIs should not imply the accuracy of a serotonin theory of depression. At best we know that the medication works, at worst we know that it's actively encouraging people to kill themselves, although the latter seems a little unlikely atp. Having been on an SSRI myself I gave up on the hope of SSRIs forming the basis of real treatment decades ago. Bupropion seems less harmful but also seems to have similarly small impact.