I'd argue that, at that point, you might as well write HTML. I find it easier to work with one format at a time rather than two intermixed and a typical Markdow

I'd argue that, at that point, you might as well write HTML. I find it easier to work with one format at a time rather than two intermixed and a typical Markdown document is barely more readable than its equivalent HTML document, while the latter gives you a lot more flexibility and semantic accuracy.