3 ms·

Yeah, I'm not sure that 'weekly' is true either, most of the research I've done says 0.5mg/kg is a single 'dose', rather than anything timebound. A lot of the p

Yeah, I'm not sure that 'weekly' is true either, most of the research I've done says 0.5mg/kg is a single 'dose', rather than anything timebound. A lot of the protocols seem to indicate that twice weekly is the most common dosing, but it depends on the usage: https://www.drugs.com/dosage/ketamine.html https://www.drugs.com/dosage/ketamine.html says 1-4.5mg/kg for anaesthesia, with more as needed to maintain https://reference.medscape.com/drug/ketalar-ketamine-343099 https://reference.medscape.com/drug/ketalar-ketamine-343099 says 0.5mg/kg for depression off label, repeated twice weekly. https://dancesafe.org/ketamine/#:~:text=30-60%20mg https://dancesafe.org/ketamine/#:~:text=30-60%20mg says that the common recreational dose is 30-60mg, so the number mentioned by the author is between 50 and 250 'bumps' a week? I'm not familiar with ketamine usage, but that seems to be a very high number.

GordonS 2y ago
ROA (route of administration) also matters, and those figures you've given appear to be a mix of IV (intravenous) and IM (intramuscular) injection doses. Many recreational users insufflate (snort) ketamine, and that ROA has much lower bioavailability than IM or IV - IIRC, it's something like 20% for insufflation, 80% for IM, and 100% for IV. Thus, you need a much higher dose for snorting.
- d1sxeyes 2y ago
  I agree. The article is unclear though. For recreational users snorting (I think it's 'insufflate', rather than insulate), the DanceSafe link is clear that that's the method (it says 'snort 30-60mg'). As you say, you'd expect users to need a much higher dosage for snorting than IV. Either way, the article has since been silently updated to remove the 100-300x claim that I took issue with, so either I, or someone else, managed to get the point across to the author.
  - GordonS 2y ago
    > I think it's 'insufflate', rather than insulate Haha, auto-correct strikes again!

GordonS 2y ago

ROA (route of administration) also matters, and those figures you've given appear to be a mix of IV (intravenous) and IM (intramuscular) injection doses. Many recreational users insufflate (snort) ketamine, and that ROA has much lower bioavailability than IM or IV - IIRC, it's something like 20% for insufflation, 80% for IM, and 100% for IV. Thus, you need a much higher dose for snorting.

d1sxeyes 2y ago
I agree. The article is unclear though. For recreational users snorting (I think it's 'insufflate', rather than insulate), the DanceSafe link is clear that that's the method (it says 'snort 30-60mg'). As you say, you'd expect users to need a much higher dosage for snorting than IV. Either way, the article has since been silently updated to remove the 100-300x claim that I took issue with, so either I, or someone else, managed to get the point across to the author.
- GordonS 2y ago
  > I think it's 'insufflate', rather than insulate Haha, auto-correct strikes again!