4 ms·

The author clarifies later that the listed therapeutic dosage is weekly rather than daily, so that's 3500-7000mg/week versus 35mg/week for an average person (fr

• pantalaimon 2y ago
  1g/day is a pretty extreme dose, even disregarding that most users don't consume it daily.
  • quchen 2y ago
    It is however not unheard of, or even uncommon. With moderate tolerance, binging a couple of hours will reach the 1g threshold quite quickly. Ketamine tolerance upon continued use can reach some really wild levels. I’ve worked with people who reported that a 1g single dose nasally won’t get them properly high.
    • amarcheschi 2y ago
      Wow, I googled and the dose for horses is about 2 to 5 mg/kg
      • quchen 2y ago
        It’s the same dose (per body mass!) for humans, and ketamine is heavily used in human medicine for similar reasons. The main difference is that for horses it’s mostly used as an anesthetic, while for humans it’s also used at lower doses as an analgesic (pain reliever).
        • amarcheschi 2y ago
          Yeah but I mean, 1g is a 200kg human dose in the best case. That's a lot
        • malfist 2y ago
          When I severely dislocated my shoulder the hospital sedated me with ketamine and propofal. They'd already given me the max dosage of morphine and fentanyl to get me to be able to barely sit up for an X-ray. So I'd say it's used in humans for anesthetic too. And guys, I'd the doc says after your first dislocation you should have the surgery to prevent it from happening again, you should listen to them so you don't spend a night in excruciating pain three months later. For what it's worth, when I came too I felt like I was black out drunk, not a good experience for a previous alcoholic
      • farbklang 2y ago
        It should be noted that in this example we are comparing insufflation vs injection, which has a very different bioavailability and effect on the body. I think for therapy with humans it is also given as a nasal spray.
        • amarcheschi 2y ago
          Oh definitely, I thought about writing about it but omitted it, I should have added it earlier
• d1sxeyes 2y ago
  Yeah, I'm not sure that 'weekly' is true either, most of the research I've done says 0.5mg/kg is a single 'dose', rather than anything timebound. A lot of the protocols seem to indicate that twice weekly is the most common dosing, but it depends on the usage: https://www.drugs.com/dosage/ketamine.html https://www.drugs.com/dosage/ketamine.html says 1-4.5mg/kg for anaesthesia, with more as needed to maintain https://reference.medscape.com/drug/ketalar-ketamine-343099 https://reference.medscape.com/drug/ketalar-ketamine-343099 says 0.5mg/kg for depression off label, repeated twice weekly. https://dancesafe.org/ketamine/#:~:text=30-60%20mg https://dancesafe.org/ketamine/#:~:text=30-60%20mg says that the common recreational dose is 30-60mg, so the number mentioned by the author is between 50 and 250 'bumps' a week? I'm not familiar with ketamine usage, but that seems to be a very high number.
  • GordonS 2y ago
    ROA (route of administration) also matters, and those figures you've given appear to be a mix of IV (intravenous) and IM (intramuscular) injection doses. Many recreational users insufflate (snort) ketamine, and that ROA has much lower bioavailability than IM or IV - IIRC, it's something like 20% for insufflation, 80% for IM, and 100% for IV. Thus, you need a much higher dose for snorting.
    • d1sxeyes 2y ago
      I agree. The article is unclear though. For recreational users snorting (I think it's 'insufflate', rather than insulate), the DanceSafe link is clear that that's the method (it says 'snort 30-60mg'). As you say, you'd expect users to need a much higher dosage for snorting than IV. Either way, the article has since been silently updated to remove the 100-300x claim that I took issue with, so either I, or someone else, managed to get the point across to the author.
      • GordonS 2y ago
        > I think it's 'insufflate', rather than insulate Haha, auto-correct strikes again!