Thank you so much for this! Would brain biopsies (if they could be performed safely, widely) be more beneficial than the multimodal/multi-omic datasets now emer

Thank you so much for this! Would brain biopsies (if they could be performed safely, widely) be more beneficial than the multimodal/multi-omic datasets now emerging that combine PET/CSF/Blood? Also, how much information would PET-ligands designed to bind to fibres and the p-tau blood test yield towards designing interventions? What exactly would they reveal that we don't know already?