It definitely depends on the person and the state of mind they have when they go into it. I've had really overwhelming de-personalization episodes on LSD as wel

It definitely depends on the person and the state of mind they have when they go into it. I've had really overwhelming de-personalization episodes on LSD as well and they were extremely positive, life transforming experiences. I had studied and practiced Buddhism for years prior to having those experiences, though, which helped me integrate what was happening. It was like all of a sudden getting a direct experience of what was previously just words and philosophy -- "oh, this is what he was talking about." Had I gone into it totally blind with no way to frame it it probably would have been a nightmarish scenario though. There's a reason why Right View (samyak-drishti) is the first of the 8 Noble Truths [1] and the one really emphasized in the beginning of your Buddhist practice. [1] https://en.wikipedia.org/wiki/View_(Buddhism) https://en.wikipedia.org/wiki/View_(Buddhism)