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I've used it for a while now on my knees and ankles. Seems like it works. But honestly its hard for me to tell if anything works. I even question Tylenol. A
by kenjackson 2y ago
I've used it for a while now on my knees and ankles. Seems like it works. But honestly its hard for me to tell if anything works. I even question Tylenol. All of it seems like it may work some, but its not something I feel has a very acute impact at all.
Without a controlled study, as an individual, how can I tell if my sprain got better in 6 days but would've taken 9 days otherwise???
- anon84873628 2y agoYou might want to look into BPC-157
- andreareina 2y agoBPC 157 has little to no reliable data to say it works. https://open.spotify.com/episode/6WLUUia6qZjVredWBuOlr6 https://open.spotify.com/episode/6WLUUia6qZjVredWBuOlr6
- cjbgkagh 2y agoA fair amount of anecdotal data though, it has helped me and others that I know. While the effect is pretty mild it is positive. Having a lifelong chronic condition I’m very sensitive to changes and have no discernible placebo effect. I’ve tried so many things that my prior belief when trying something new is that it wont work, so it’s a nice unexpected surprise when it does.
- BobaFloutist 2y agoGhosts have a fair amount of anecdotal data. Homeopathy has a fair amount of anecdotal data.
- cjbgkagh 2y agoI am aware of survivorship bias but for that to apply BPC157 would have to be killing people, this peptide is widely used so if it was killing people we would know due to investigations into their deaths. People usually hear about this stuff peer to peer and they report back to their peers if it helped or not, so there is a before and after, and for those people there isn’t a selection criteria biased on success. If people don’t report back then others become very interested in why.
- anon84873628 2y agoI don't think "ghosts" was meant to imply the compound is killing people, just give an example of something people believe in without scientific evidence.
- cjbgkagh 2y agoFair point, I did misread the comment as a selection bias as opposed to a 'Reductio ad absurdum' argument. Insulin and Ozempic are both bioactive peptides, which is not to say BPC157 is anywhere as strong as either of them, but it's not easily dismissed either. Nowhere near the absurdities of ghosts and homeopathy.
- BobaFloutist 2y agoOk, fine, compare it instead to misleading anecdotal evidence surrounding dietary supplements. We know vitamins(/minerals/whatever) are compounds that are strictly necessary for life. We know that some health outcomes are tied to deficiencies or surpluses of these molecules. We know that in some, very specific cases, a disease is most effectively treated with OTC supplements. We also know that, despite the vast quantities of anecdotal evidence readily available, taking 500% of your recommended daily value of Vitamin C will not actually effect the duration of your upper-respiratory tract infection. In fact, even ignoring the quality control issues in many commercial supplements, sometimes you can't even treat the deficiency of a specific nutrient with oral supplementation. And yet, again, many people will happily attest to the lifechanging benefits of supplementation to counteract a deficiency they likely never had.
- cjbgkagh 2y agoOk, some people are crazy therefore all anecdotal data is useless? Seems like a bit of a stretch. Someone tells you the weather is nice outside do you demand to see a peer reviewed study to that effect?
- kjs3 2y agoKilling people? So bad at reading for comprehension and science.
- monero-xmr 2y agoSleep on a firm mattress. Stretch daily. Lift weights 3x a week, for 2x upper body focus and 1x leg day. Cardio 3x a week on days you don’t lift. High protein and low fat every day. Low sugar and carbs. Pain comes as you age. It isn’t unique to modern man, other than we typically live longer than ancient man. If you do this plan you can still cheat. Drink, party, eat whatever. You invest effort so you can enjoy life when the moment arises.
- raffraffraff 2y agoActually the "drink plenty" thing, if you're referring to alcohol, isn't something I can do. I quit (or cut down to insignificant levels) after observing is effect on me via my Garmin stats. Everything goes bad: HRV drops, resting heart rate goes up and sleep scores is terrible. One beer or one glass of white wine with a meal around 6pm is ok. But a night out with the guys makes me look like a very sick 80 year old. Heart rate barely drops below 80 while I'm asleep. Normally it's 48-54 BPM through the night. And if I go for a light run the day after having two or three beers, my heart rate is at least 20 BPM higher. So I made a rule: no exertion after alcohol, no alcohol when I'm already compromised (eg: unwell, when those stats are already bad)
- beagle3 2y agoWhich Garmin model do you use? Do you know if the measurements provided by an Apple Watch are as informative? Trying to decide which one to get.
- cyberpunk 2y agoThe accuracy isn’t as important as the trend. Don’t expect hospital grade ecg results but either can certainly tell you if things are better or worse since you’re wearing the same sensor. I’ve got the AW Ultra and I’m quite fond of it, ability to use it without carrying my phone (even audible audiobooks) is the killer for me.
- zanybear 2y agoI get the same values and trend after a glass of wine or rye and ginger. I have an Apple Watch.
- 14 2y agoTylenol is a pain reliever so may help with pain. Something like ibuprofen may be a better option, speak to your doctor, as it not only helps with pain but acts as an anti-inflammatory. The important thing to note is that it's effects do not happen instantly but something like several days later so if you have a knee issue, taking it regularly as directed by doctor or manufacturers instructions and not just when your knee hurts can really speed up recovery. As for your question well you basically just have to trust the science. At some point a rat in a lab probably was intentionally injured next to another rat in the same position and one would get the treatment and the other not. They would then see who healed faster. Things like Acetaminophen and Ibuprofen have been around a long time and studied extensively so they have a good understanding of it's efficacy. Lastly placebo effect seems to be a real effect so if you do something and you think it might help it might help.
- lazide 2y agoIbuprofen has some well known (and negative) side effects, including ulcers, increased risk of stroke and heart attack, and even significantly increased malformed sperm production [https://www.sciencedirect.com/science/article/abs/pii/S0045653523029879#:~:text=We%20found%20that%20early%2Dlife,in%20unexposed%20males%20(11%25). https://www.sciencedirect.com/science/article/abs/pii/S00456...] Vitamin I is not, well, actually a vitamin.
- literalAardvark 2y agoIt also drastically lowers the integrity of rebuilt tendon/ligament, say after a sprain. Seems all that inflammation might actually be doing something.
- LoganDark 2y agopoor rat :(
- andriesm 2y agoNo they're lucky, all the best medical discoveries are for them.
- tristramb 2y agoYou need to sprain both knees or ankles at the same time and then use one as the control.
- differentView 2y agoBoth most people favor one side of their body, so the wear and tear would already be uneven.
- aghilmort 2y agomost useful comment in thread like that H.pylori ulcer discovery