2 ms·
Yeah, seems like an easyish study to do. "Does EHR data show that patients on Prozac have a lower mortality rate from sepsis than the general population." > I
by cogman10 2y ago
Yeah, seems like an easyish study to do. "Does EHR data show that patients on Prozac have a lower mortality rate from sepsis than the general population."
> I’m not even sure how this would be implemented in practice: at what point would patients be given SSRIs?
Perhaps right before and after a surgery when infection is possible?
- BobbyJo 2y agoFluoxetine has an insanely long half life, and your brain is sensitive to its affects. Not really a viable option for acute treatment.
- cogman10 2y ago> Fluoxetine has an insanely long half life The half life is 7 days. > your brain is sensitive to its affects. It takes time for SSRIs to take effect. Acute usage is probably ideal as you wouldn't be dealing with withdraw symptoms.
- BobbyJo 2y ago1) 7 days is a long time. 2) I believe you are confusing the common progressive dosage regimens with delayed effects. The reason fluoxetine typically takes time before you feel effects is because you take a small daily dose that build up in your system over time. It builds up since dosing is more frequent than the drugs half life. 3) Acute intake is associated with side effects, not just acute withdrawal.