3 ms·
> and not having the predictive power to know how a given protein will interact with the countless atoms and molecules in the countless, somewhat arbitrary, ran
by gus_massa 2y ago
> and not having the predictive power to know how a given protein will interact with the countless atoms and molecules in the countless, somewhat arbitrary, random human bodies.
You test it first in mice. If the new drug has not nasty side effects, you try it in other animals, then in monkeys, then voluntairs and then in pilot trial with humans.
- perching_aix 2y ago> short of a regular clinical trial gauntlet
- AStonesThrow 2y agoNah you just make a Russian Roulette menu out of pharmaceutical offerings and continually parade new chemicals through the marketing machine as the patent granting/expiration cycle chews through them. You run costly ad campaigns and multimedia commercials, and you send salesmen out with imprinted pens and fancy notepads and they hand those things to the physician, then they purchase a nice lunch for the clinicians and explain how they treat all the weird nouveau conditions that were coined specifically for this drug. Do not Taunt Happy Fun Ball Then the insurance companies get on board with "fail-first step therapy" and the physicians start writing the cheapest prescriptions possible in hopes that the patient will go away or so totally fuckin' placebo'd that they were so busy filling scrips that they wouldn't bother complaining about the same thing twice. Can you tell that I immensely enjoyed Hank Azaria, Jake Gylenhaal, and Anne Hathaway in "Love & Other Drugs"?
- gus_massa 2y agoMice are cheaper. And in case of a problem the family doesn't sue you and the press doesn't pretend to be angry for a week.