No, I'm assuming there's a tradeoff between sensitivity (spotting cancers) and specificity (having your positive results actually be cancer). ANOVA to pick var

No, I'm assuming there's a tradeoff between sensitivity (spotting cancers) and specificity (having your positive results actually be cancer). ANOVA to pick variables and then reasonably selecting thresholds is a fine process that avoids overfit. The big problem is, biology is messy and measuring lots of people to find correct thresholds is really expensive and time consuming. It's not really a technological problem, though technology has helped a little.