Well, given that the Supreme Court punted on the question of software patents in Bilski, I'd say the best way would be to call your Senators and Congressperson

Well, given that the Supreme Court punted on the question of software patents in Bilski, I'd say the best way would be to call your Senators and Congressperson and ask them to draft legislation to abolish software patents. But, good luck on that. Bilski is over 2 years old now, and the status quo is still in place.