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I would posit that whoever is saying they’re unreliable has an agenda. Are they 100% accurate in the sense of being able to determine whether you’re 6.2 vs 6.3%
by transcriptase 2y ago
I would posit that whoever is saying they’re unreliable has an agenda. Are they 100% accurate in the sense of being able to determine whether you’re 6.2 vs 6.3% Italian? No, there’s always a small degree of uncertainty as more genomes are sequenced and reference panels are updated, but at this point unless you’re from an isolated tribe in the Amazon or some incredibly niche case they’re very representative.
Most people don’t necessarily understand recombination and that if three of your grandparents are Danish and one of your grandparents is, Italian, then you are going to be on average 25% Italian… but that it’s also a distribution centred around 25%. By luck of the draw you could be 3% or you could be 45% Italian genome-wise. People might base their identity on being 1/4 this or 1/8 that, and be upset when an ancestry report gives the actual %.
- graemep 2y agoThe problem is that most genes are mixed over very wide areas. List of published research on the consequences https://www.ucl.ac.uk/biosciences/understanding-genetic-ancestry-testing https://www.ucl.ac.uk/biosciences/understanding-genetic-ance... You can see this by looking at genes with observable consequences such as lactose tolerance. While there are multiple genes for this AFAIK, the commonest is spread over a huge area. Something as specific as "Danish" or "Italian" genes looks illusory.