3 ms·
I’ve said nothing of the sort. I’m also well aware of the concept of admixture and that dimensionality reduction methods like PCA and MDS with enough samples mi
by transcriptase 2y ago
I’ve said nothing of the sort. I’m also well aware of the concept of admixture and that dimensionality reduction methods like PCA and MDS with enough samples mirror geography. I also know that the variants contributing the most to the X and Y axes of such analyses are the ones with a high FST, because unsurprisingly prior to a few hundred years ago people didn’t move around that much and were subject to different genetic bottlenecks and selection pressures. And most alleles are rare, so when one is fixed between populations it’s generally informative from an ancestry standpoint even if non-coding.
Your reflexive dismissal of something that’s not only factual but wouldn’t be controversial about any vertebrate except humans is exactly what I was alluding to.