4 ms·

I’ve felt my best on a carnivore diet but couldn’t keep a stable weight so I fear it’s the equivalent of saying I felt my best when I was slowly dying of hunger

by mentos 2y ago

I’ve felt my best on a carnivore diet but couldn’t keep a stable weight so I fear it’s the equivalent of saying I felt my best when I was slowly dying of hunger? ha I have done 23andMe where can I look for those genes?

yuppii 2y ago
Could you elaborate a bit more about the diet and its effects?
gns24 2y ago
Yeah, I'm always a bit suspicious of apparently effective dietary changes which result in a calorie reduction - often different people report completely different dietary changes helped them, but one thing they all have in common is being in calorie deficit. There are plenty of studies showing that caloric restriction calms inflammatory responses which are responsible for the majority of common diseases. Without balancing the energy intake, I'm always slightly suspicious that any improvements with changing what I eat are actually caused by the change in how much I eat.
- ddorian43 2y ago
  There are many people who've never been fat and felt better in keto/carnivore. Example:me. Another example is https://reddit.com/user/MythicalStrength https://reddit.com/user/MythicalStrength who's a strongman competitor. > often different people report completely different dietary changes helped them Nobody fixed T2D, (some types of) epilepsy, (some cases of) mental illness like bipolar/psychosis on high carb or high protein.
- s1artibartfast 2y ago
  I dont think this is an either/or question. I think people struggle with multiple levels of explanation, which is almost always the case in biology, psychology, and behavior. There is also a huge amount of biologic variability between people. As a result, some people may find it more pleasant and easier to balance energy intake with different dietary styles.
ddorian43 2y ago
Should be easy to troubleshoot on a forum or with a specialist. You probably were eating low fat. It happens often. Feel free to describe exactly what you ate and what problems you had.
jjallen 2y ago
Just FYI this is not carnivore and I have mostly fixed this without eating pure meat. You can take methylated folate to fix this problem. One of the subject genes is called MTHFR. It reduces the methylation of Folic acid by ~30-40%, depending on which paper you read. Tons of people have this. It was this AND a gluten sensitivity which resulted in me having actually low levels of usable folate. To find out if you have this go to this link: https://you.23andme.com/tools/data/?query=MTHFR https://you.23andme.com/tools/data/?query=MTHFR. You can enter various other SNPs there if you find any of interest. You can download your DNA there and enter it in another site that can tell you the other genes that could affect this sort of thing. There are other things that could affect other people in unique ways so of course this isn't the only one. What I did is ask Claude "why would eating meat make me feel dramatically better" and it told me about these genes. And then I went to 23andme where you can see individual SNPs and then I searched for other related SNPs. I also seem to have non-Celiac gluten sensitivity which affects my absorption of Folate (and other things if I have recently eaten gluten which was almost always until recently) which is why this was a problem for me. And zero doctors or companies have ever developed a test for this or even take it seriously, including allergists and immunologists that I saw.
- criddell 2y ago
  23andme say this about MTHFR: > Despite lots of research – and lots of buzz – the existing scientific data doesn’t support the vast majority of claims that common MTHFR variants impact human health. https://blog.23andme.com/articles/our-take-on-the-mthfr-gene https://blog.23andme.com/articles/our-take-on-the-mthfr-gene Is their take on MTHFR out of date?
  - Aurornis 2y ago
    No, it’s correct. MTHFR as told by the internet is an alternative medicine topic. It has been abused by influencers and supplement sellers because it’s extremely common to have one of these variants. The influencers use it as an “aha!” moment because most people who go looking for it will have it. Most of the internet advice about MTHFR is completely without basis in science. If you have one of the rarer homozygous mutations then it’s worth looking at, but it’s not the explanation for all ills that you see from influencers. Chances are good that if you’re reading this, healthy or not, you have a MTHFR variant. It does not mean anything by itself. Methylfolate is also used as an adjunct to antidepressants because it has some efficacy in depression in some cases. That fact is probably not coincidental to all of these reports about people feeling “better” when they start taking it. MTHFR may not even be involved at all.

by mentos 2y ago

yuppii 2y ago

Could you elaborate a bit more about the diet and its effects?

gns24 2y ago

Yeah, I'm always a bit suspicious of apparently effective dietary changes which result in a calorie reduction - often different people report completely different dietary changes helped them, but one thing they all have in common is being in calorie deficit. There are plenty of studies showing that caloric restriction calms inflammatory responses which are responsible for the majority of common diseases. Without balancing the energy intake, I'm always slightly suspicious that any improvements with changing what I eat are actually caused by the change in how much I eat.

ddorian43 2y ago
There are many people who've never been fat and felt better in keto/carnivore. Example:me. Another example is https://reddit.com/user/MythicalStrength https://reddit.com/user/MythicalStrength who's a strongman competitor. > often different people report completely different dietary changes helped them Nobody fixed T2D, (some types of) epilepsy, (some cases of) mental illness like bipolar/psychosis on high carb or high protein.
s1artibartfast 2y ago
I dont think this is an either/or question. I think people struggle with multiple levels of explanation, which is almost always the case in biology, psychology, and behavior. There is also a huge amount of biologic variability between people. As a result, some people may find it more pleasant and easier to balance energy intake with different dietary styles.

ddorian43 2y ago

Should be easy to troubleshoot on a forum or with a specialist. You probably were eating low fat. It happens often. Feel free to describe exactly what you ate and what problems you had.

jjallen 2y ago

Just FYI this is not carnivore and I have mostly fixed this without eating pure meat. You can take methylated folate to fix this problem. One of the subject genes is called MTHFR. It reduces the methylation of Folic acid by ~30-40%, depending on which paper you read. Tons of people have this. It was this AND a gluten sensitivity which resulted in me having actually low levels of usable folate. To find out if you have this go to this link: https://you.23andme.com/tools/data/?query=MTHFR https://you.23andme.com/tools/data/?query=MTHFR. You can enter various other SNPs there if you find any of interest. You can download your DNA there and enter it in another site that can tell you the other genes that could affect this sort of thing. There are other things that could affect other people in unique ways so of course this isn't the only one. What I did is ask Claude "why would eating meat make me feel dramatically better" and it told me about these genes. And then I went to 23andme where you can see individual SNPs and then I searched for other related SNPs. I also seem to have non-Celiac gluten sensitivity which affects my absorption of Folate (and other things if I have recently eaten gluten which was almost always until recently) which is why this was a problem for me. And zero doctors or companies have ever developed a test for this or even take it seriously, including allergists and immunologists that I saw.

criddell 2y ago
23andme say this about MTHFR: > Despite lots of research – and lots of buzz – the existing scientific data doesn’t support the vast majority of claims that common MTHFR variants impact human health. https://blog.23andme.com/articles/our-take-on-the-mthfr-gene https://blog.23andme.com/articles/our-take-on-the-mthfr-gene Is their take on MTHFR out of date?
- Aurornis 2y ago
  No, it’s correct. MTHFR as told by the internet is an alternative medicine topic. It has been abused by influencers and supplement sellers because it’s extremely common to have one of these variants. The influencers use it as an “aha!” moment because most people who go looking for it will have it. Most of the internet advice about MTHFR is completely without basis in science. If you have one of the rarer homozygous mutations then it’s worth looking at, but it’s not the explanation for all ills that you see from influencers. Chances are good that if you’re reading this, healthy or not, you have a MTHFR variant. It does not mean anything by itself. Methylfolate is also used as an adjunct to antidepressants because it has some efficacy in depression in some cases. That fact is probably not coincidental to all of these reports about people feeling “better” when they start taking it. MTHFR may not even be involved at all.