3 ms·
I am not sure what you mean by interleaved here. In 2013 I am not sure that site differences were as appreciated as they are today. Today, in studies that use m
by SubiculumCode 2y ago
I am not sure what you mean by interleaved here.
In 2013 I am not sure that site differences were as appreciated as they are today. Today, in studies that use multi-site imaging data, ComBat Harmonization is often the method that is employed to account for site effects in two ways: (1) it models site-specific scaling factors and (2) it uses empirical Bayes to improve the estimation of the site parameters for small sample sizes. https://pmc.ncbi.nlm.nih.gov/articles/PMC5845848/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5845848/
- robwwilliams 2y agoBy interleaved I mean that cases and controls were not each in their own run batches, but ideally run A ,B, A, B, Yes ComBat can some of the batch effect if sample sizes are large enough. But here as you point out they are on thin ice.