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Vinod, often flashy and interesting, also often plays a bit fast and loose..a strategy that seems to land his lab good journals, but questionable replication. S
by SubiculumCode 2y ago
Vinod, often flashy and interesting, also often plays a bit fast and loose..a strategy that seems to land his lab good journals, but questionable replication. So I immediately looked at the preprocessing steps in the methods...which is, annoyingly, in supplemental 1. A few comments:
It is written so vaguely, it is difficult to understand what preprocessing steps were done and in which order (which matters). The steps to avoid motion confounds mostly talk about why they didn't do certain things (e.g. GSR regression), and not what they did do (tissue signal covariates?), what about non-GSR based noise cleaning to remove physiological and motion related noise? The study may be good,I just wish it was written more straightforwardly, and less like they are weaving past potential reviewer objections.
Vinod (v) To Vinod a paper is to write it so loose and sexy, so fast and seductive, editors are bound to wake up the morning after with a new babe. (Just a little joke among some colleagues of mine).
- robwwilliams 2y agoAmusing comments provided you are not Vinod. Three sites and I would hope that connectomes were computed interleaved between cases and controls and analyzed with blinding. Is that standard? Do you think behavioral difference in the scanner could generate false positive connectome differences?
- SubiculumCode 2y agoI am not sure what you mean by interleaved here. In 2013 I am not sure that site differences were as appreciated as they are today. Today, in studies that use multi-site imaging data, ComBat Harmonization is often the method that is employed to account for site effects in two ways: (1) it models site-specific scaling factors and (2) it uses empirical Bayes to improve the estimation of the site parameters for small sample sizes. https://pmc.ncbi.nlm.nih.gov/articles/PMC5845848/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5845848/
- robwwilliams 2y agoBy interleaved I mean that cases and controls were not each in their own run batches, but ideally run A ,B, A, B, Yes ComBat can some of the batch effect if sample sizes are large enough. But here as you point out they are on thin ice.
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- bogtog 2y agoIs it too bold to say that any 10+ year old study claiming to have found across-subject brain x behavior relationship is not worth looking at closely?
- SubiculumCode 2y agoHa. I didn't even notice the date.
- deleted 2y ago[deleted]