It wouldn't surprise me if you could do this with a RP2350, connecting GPIOs to the same location as the 65C02 does on the breadboard and even running emulated

It wouldn't surprise me if you could do this with a RP2350, connecting GPIOs to the same location as the 65C02 does on the breadboard and even running emulated 6502 code. It's totally not the same thing of course. A whole lot of transistors and clock speed go to making that feat possible.