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Adhibin identified as an active agent against cancer metastasis
- adamredwoods 2y agoCould be massive, if holds true. Metastasis is the killer. >> In his working group, Professor Tsiavaliaris is conducting research into myosin motors. These motor proteins are mini-machines that drive many vital processes in our cells, including force and movement. They transport small 'packages' within the cell and interact with the cytoskeleton, a dynamic scaffold of filaments and tubes that extends from the cell nucleus to the cell membrane. >> In addition, myosins reduce the activity of Rho GTPases and are therefore particularly interesting as anti-metastatic targets. >> "My research team has discovered a synthetic agent called Adhibin that inhibits the motor function of myosins and thus inhibits the Rho proteins even more," says the biochemist. This suppresses the Rho-GTPase-mediated mechanisms of metastasis. >> As a result, tumor cells can no longer migrate undisturbed and cannot attach themselves to other sites.