Good question! It's possible that this will eventually happen, but I think it's unlikely for 2 reasons: Lots of stuff goes through a small area in the carpal t

Good question! It's possible that this will eventually happen, but I think it's unlikely for 2 reasons: Lots of stuff goes through a small area in the carpal tunnel so it's easy for it to all rub too much and get irritated. My understanding is that the extensors don't all go through a similar narrow area so are less likely to have this problem. The flexors are used a lot for typing. By moving some of the wear from mousing to the extensors, the idea is to better spread out the wear and tear.