I really appreciate your explanation regarding the crud factor. It adds a lot of intuition. Out of curiosity, what is your perspective on gnotobiotic systems?

I really appreciate your explanation regarding the crud factor. It adds a lot of intuition. Out of curiosity, what is your perspective on gnotobiotic systems? I distinctly recall an example of a gnotobiotic mouse that, upon being provided a microbial sample from an obese mouse, started to have substantial increases in body fat despite a simultaneous reduction in feed. Would that type of experimental approach still run into the statistical difficulties you mentioned?