The first two, screen wake lock and web serial have good use cases imo. I wouldn’t be surprised if some in-use assistive technology uses serial communication -

The first two, screen wake lock and web serial have good use cases imo. I wouldn’t be surprised if some in-use assistive technology uses serial communication - think screen readers or custom input devices. Keeping the screen from locking is also useful from a purely accessible standpoint as well for users who move slower or need more time to read things.