4 ms·

So glad I am not the only one here interested in personal genomics. For example; I a FUT2 non-secretor. Understanding this changes my life and my IBD. I also h

So glad I am not the only one here interested in personal genomics. For example; I a FUT2 non-secretor. Understanding this changes my life and my IBD. I also have NOD2 polymorphisms linked to Crohn's and skin problems. Also Lactose intolerant so... Understanding this led to the reduction of so much of my pain, mental and physical. I also have a Partial PNP Deficiency but I will let you look that up.

Dowwie 2y ago
what did you change in your diet / lifestyle after you learned about your genetic makeup?
- FollowingTheDao 2y ago
  Sorry for the late response. I want to preface by saying I have some serious health issues that they have not been able to sort out over the last 30 years of my life, and genetically I am a rarity, probably link to my Sami heritage. For my FUT2 non-secretor status I eat a lot of seaweed and mushrooms. The Fucose in these foods replaces the Fucose I am not secreting in my intestines. FUT2 is a fucosyltransferase. This helps the bacteria attach to the Fucsoe and not invade my gut. https://pubmed.ncbi.nlm.nih.gov/34151459/ https://pubmed.ncbi.nlm.nih.gov/34151459/ For the NOD2 I just need to be really careful about infections. If it were not fro my FUT2 non-secetor status that protects me against E. Coli infection I would for sure have Crohn's https://pmc.ncbi.nlm.nih.gov/articles/PMC2924159/ https://pmc.ncbi.nlm.nih.gov/articles/PMC2924159/ Based on my PUFA genetics I eat a lot of high omega 3 seafoods and no plant oils. https://pmc.ncbi.nlm.nih.gov/articles/PMC5672832/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5672832/ But my big problem is that I have a Partial PNP deficiency. So no sugars and very low calorie diet. https://pmc.ncbi.nlm.nih.gov/articles/PMC7338719/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7338719/ Those are the big ones.
zhs 2y ago
Yes! I'm also curious what specific changes you made related to your IBD protocols backed up by your genetic predispositions.
arrosenberg 2y ago
Presence of FUT2 and FUT3 also have very interesting impacts on CA19-9 levels, which affects cancer detection - https://pubmed.ncbi.nlm.nih.gov/23958938/ https://pubmed.ncbi.nlm.nih.gov/23958938/

Dowwie 2y ago

what did you change in your diet / lifestyle after you learned about your genetic makeup?

FollowingTheDao 2y ago
Sorry for the late response. I want to preface by saying I have some serious health issues that they have not been able to sort out over the last 30 years of my life, and genetically I am a rarity, probably link to my Sami heritage. For my FUT2 non-secretor status I eat a lot of seaweed and mushrooms. The Fucose in these foods replaces the Fucose I am not secreting in my intestines. FUT2 is a fucosyltransferase. This helps the bacteria attach to the Fucsoe and not invade my gut. https://pubmed.ncbi.nlm.nih.gov/34151459/ https://pubmed.ncbi.nlm.nih.gov/34151459/ For the NOD2 I just need to be really careful about infections. If it were not fro my FUT2 non-secetor status that protects me against E. Coli infection I would for sure have Crohn's https://pmc.ncbi.nlm.nih.gov/articles/PMC2924159/ https://pmc.ncbi.nlm.nih.gov/articles/PMC2924159/ Based on my PUFA genetics I eat a lot of high omega 3 seafoods and no plant oils. https://pmc.ncbi.nlm.nih.gov/articles/PMC5672832/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5672832/ But my big problem is that I have a Partial PNP deficiency. So no sugars and very low calorie diet. https://pmc.ncbi.nlm.nih.gov/articles/PMC7338719/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7338719/ Those are the big ones.

zhs 2y ago

Yes! I'm also curious what specific changes you made related to your IBD protocols backed up by your genetic predispositions.

arrosenberg 2y ago

Presence of FUT2 and FUT3 also have very interesting impacts on CA19-9 levels, which affects cancer detection - https://pubmed.ncbi.nlm.nih.gov/23958938/ https://pubmed.ncbi.nlm.nih.gov/23958938/