3 ms·

Huh, so the only side effect of eating more than 6lbs of cheese every day for almost a year is a minor painless cosmetic issue?

by abtinf 2y ago

venv 2y ago
Until the cardiac arrest.
- abtinf 2y ago
  The abstract did not make that claim.
  - mdaverde 2y ago
    But others do
  - vallode 2y ago
    The abstract mentions the patients cholesterol level is 1000mg/dL which is at least 4 times more than the "highly dangerous" bracket. Evidence seems to show that xanthelasma (the nodules seen on this person) can have a link to a higher risk of atherosclerosis, which is linked to high cholesterol in the first place. This will not be "asymptomatic" for ever.
Hnrobert42 2y ago
And his cholesterol was 5 times normal.
- abtinf 2y ago
  That’s my question — the abstract says he seemed otherwise healthy except for this cosmetic issue.
- datadeft 2y ago
  What is normal?
  - ethbr1 2y ago
    Total less than 200 mg/dL. ... not 1000 mg/dL.
  - djoldman 2y ago
    > The patient’s cholesterol level exceeded 1000 mg/dL ...significantly higher than his baseline of level of 210 to 300 mg/dL.
tux3 2y ago
The atherosclerosis is invisible, until it suddenly isn't. Everyone will have a little bit of plaque, even if you try to eat well. Teenagers will already have traces of it before they reach adulthood. All you can do is try to slow down the buildup. And, well, this ain't it.
- pipes 2y ago
  Genuine question, as far as I can tell there seems to be some debate currently about weather high saturated fat diets are linked with heart disease. Does atherosclerosis fall into this debate too?
  - KempyKolibri 2y ago
    Yes, high SFA diets are associated with increased risk of CVD via atherosclerosis as a result of the increase in ApoB concentration in the blood (response to retention hypothesis). This review paper is a really good overview of the model, and it's actually pretty approachable: https://academic.oup.com/eurheartj/article/41/24/2313/5735221 https://academic.oup.com/eurheartj/article/41/24/2313/573522...
    - pipes 2y ago
      Thanks
- FooBarBizBazz 2y ago
  I suppose that's true normally, but I was pleased to read that you can probably reverse it if you make radical enough changes: https://www.health.harvard.edu/heart-health/ask_the_doctor_is_it_possible_to_reverse_coronary_artery_disease https://www.health.harvard.edu/heart-health/ask_the_doctor_i...
  - tux3 2y ago
    ... where "radical enough change" in this article refers to the period of starvation during WW2! My understanding is that we don't have contemporary evidence of people successfully reverting arterial plaque, but I admit the studies probably didn't faithfully reproduce these starvation conditions!
joekrill 2y ago
That's not even a remotely good takeaway from this. The paper is specifically focused on the "yellowish nodules", ultimately diagnosed as xanthelasma. It's not meant to be a thorough assessment of the guy's health. It doesn't imply anything about other ailments or lack thereof.

Huh, so the only side effect of eating more than 6lbs of cheese every day for almost a year is a minor painless cosmetic issue?

by abtinf 2y ago

Huh, so the only side effect of eating more than 6lbs of cheese every day for almost a year is a minor painless cosmetic issue?

venv 2y ago

Until the cardiac arrest.

abtinf 2y ago
The abstract did not make that claim.
- mdaverde 2y ago
  But others do
- vallode 2y ago
  The abstract mentions the patients cholesterol level is 1000mg/dL which is at least 4 times more than the "highly dangerous" bracket. Evidence seems to show that xanthelasma (the nodules seen on this person) can have a link to a higher risk of atherosclerosis, which is linked to high cholesterol in the first place. This will not be "asymptomatic" for ever.

Hnrobert42 2y ago

And his cholesterol was 5 times normal.

abtinf 2y ago
That’s my question — the abstract says he seemed otherwise healthy except for this cosmetic issue.
datadeft 2y ago
What is normal?
- ethbr1 2y ago
  Total less than 200 mg/dL. ... not 1000 mg/dL.
- djoldman 2y ago
  > The patient’s cholesterol level exceeded 1000 mg/dL ...significantly higher than his baseline of level of 210 to 300 mg/dL.

tux3 2y ago

The atherosclerosis is invisible, until it suddenly isn't. Everyone will have a little bit of plaque, even if you try to eat well. Teenagers will already have traces of it before they reach adulthood. All you can do is try to slow down the buildup. And, well, this ain't it.

pipes 2y ago
Genuine question, as far as I can tell there seems to be some debate currently about weather high saturated fat diets are linked with heart disease. Does atherosclerosis fall into this debate too?
- KempyKolibri 2y ago
  Yes, high SFA diets are associated with increased risk of CVD via atherosclerosis as a result of the increase in ApoB concentration in the blood (response to retention hypothesis). This review paper is a really good overview of the model, and it's actually pretty approachable: https://academic.oup.com/eurheartj/article/41/24/2313/5735221 https://academic.oup.com/eurheartj/article/41/24/2313/573522...
  - pipes 2y ago
    Thanks
FooBarBizBazz 2y ago
I suppose that's true normally, but I was pleased to read that you can probably reverse it if you make radical enough changes: https://www.health.harvard.edu/heart-health/ask_the_doctor_is_it_possible_to_reverse_coronary_artery_disease https://www.health.harvard.edu/heart-health/ask_the_doctor_i...
- tux3 2y ago
  ... where "radical enough change" in this article refers to the period of starvation during WW2! My understanding is that we don't have contemporary evidence of people successfully reverting arterial plaque, but I admit the studies probably didn't faithfully reproduce these starvation conditions!

joekrill 2y ago

That's not even a remotely good takeaway from this. The paper is specifically focused on the "yellowish nodules", ultimately diagnosed as xanthelasma. It's not meant to be a thorough assessment of the guy's health. It doesn't imply anything about other ailments or lack thereof.