6 ms·

The mystery being 'what causes ulcers', and the answer being Helicobacter pylori instead of stress.

by camtarn 2y ago

thomasfedb 2y ago
The previous dogma being that no bacteria could survive in the acidic conditions (pH ~2) of the stomach.
throw83489448 2y ago
Nice, but most people have some helicobacter without much problems. Some ulcers are not even caused by helicobacter.
Retric 2y ago
He discovered an effective treatment for many ulcers, but the older one also tended to work. Stress harms the immune system so many people who dramatically reduced stress showed meaningful improvement. One of those it’s better than a placebo treatments where the method of action was poorly understood.
- H_Pylori 2y ago
  [dead]
- manmal 2y ago
  H Pylori builds biofilm, and can even hide in fungal vacuoles to avoid immune system action: https://pmc.ncbi.nlm.nih.gov/articles/PMC8101746/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8101746/ It’s one of those cases where some bodies might just not be able to finish it off even in ideal conditions.
  - Retric 2y ago
    It was less effective, but treatments that work on say 1/2 the population aren’t useless. It’s a tricky thing in medicine. In then 90’s people discovered Leptin a hormone released by fat which when given to people dieting significantly reduced cravings and increased energy expenditure enabling long term weight loss. https://pmc.ncbi.nlm.nih.gov/articles/PMC2430504/ https://pmc.ncbi.nlm.nih.gov/articles/PMC2430504/ “rodents and humans that become obese on a high-fat (Western) diet do not respond to leptin” Unlike GLP-1 antagonists it did almost nothing to start the process of weight loss, but having a drug to give to people who lost 20+lb which would then help them keep it off could have helped a lot of people.
    - manmal 2y ago
      I remember cheat days in low carb diets were touted as leptin reset days.
      - Retric 2y ago
        Sadly it was BS the underlying mechanisms aren’t so easy to fool. However the information was being transmitted from individual fat cells to the rest of the body through chemical pathways we can fool via drugs.
deleted 2y ago
[deleted]

The mystery being 'what causes ulcers', and the answer being Helicobacter pylori instead of stress.

thomasfedb 2y ago

The previous dogma being that no bacteria could survive in the acidic conditions (pH ~2) of the stomach.

throw83489448 2y ago

Nice, but most people have some helicobacter without much problems. Some ulcers are not even caused by helicobacter.

Retric 2y ago

He discovered an effective treatment for many ulcers, but the older one also tended to work. Stress harms the immune system so many people who dramatically reduced stress showed meaningful improvement. One of those it’s better than a placebo treatments where the method of action was poorly understood.

H_Pylori 2y ago
[dead]
manmal 2y ago
H Pylori builds biofilm, and can even hide in fungal vacuoles to avoid immune system action: https://pmc.ncbi.nlm.nih.gov/articles/PMC8101746/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8101746/ It’s one of those cases where some bodies might just not be able to finish it off even in ideal conditions.
- Retric 2y ago
  It was less effective, but treatments that work on say 1/2 the population aren’t useless. It’s a tricky thing in medicine. In then 90’s people discovered Leptin a hormone released by fat which when given to people dieting significantly reduced cravings and increased energy expenditure enabling long term weight loss. https://pmc.ncbi.nlm.nih.gov/articles/PMC2430504/ https://pmc.ncbi.nlm.nih.gov/articles/PMC2430504/ “rodents and humans that become obese on a high-fat (Western) diet do not respond to leptin” Unlike GLP-1 antagonists it did almost nothing to start the process of weight loss, but having a drug to give to people who lost 20+lb which would then help them keep it off could have helped a lot of people.
  - manmal 2y ago
    I remember cheat days in low carb diets were touted as leptin reset days.
    - Retric 2y ago
      Sadly it was BS the underlying mechanisms aren’t so easy to fool. However the information was being transmitted from individual fat cells to the rest of the body through chemical pathways we can fool via drugs.

deleted 2y ago

[deleted]