Unfortunately, while the Novec family had ideal properties for immersion cooling applications (and have been fairly widely used in these applications), they are

Unfortunately, while the Novec family had ideal properties for immersion cooling applications (and have been fairly widely used in these applications), they are also PFAS. Many of their "advantages" relative to mineral oil fluids come from a handling perspective (e.g. no smell, no obvious residue on immersed items, not flammable), but any handling just means you're unknowingly spreading PFAS around your working area. If you have to treat (appropriately) immersion-cooled systems using Novec as containing persistent environmental contaminants, the handling "advantages" aren't so clear.