3 ms·
You provided no references, and you've made your claims in generally nonstandard terms. Given that, I don't think it's reasonable to criticize other users for g
by tripletao 2y ago
You provided no references, and you've made your claims in generally nonstandard terms. Given that, I don't think it's reasonable to criticize other users for guessing incorrectly what you meant to say.
> There are studies pre SARS-CoV-2 about coronavirus in natural environments (like bat caves), and they found motifs that we found also in SARS-CoV-2.
You're doing it again here, but I think you're probably referring to Andersen's Proximal Origin:
https://www.nature.com/articles/s41591-020-0820-9 https://www.nature.com/articles/s41591-020-0820-9
But nobody disputes that SARS-CoV-2 evolved mostly in bats; the question is whether its path from bats to humans included a trip through the lab. No genomic evidence can distinguish between a novel natural virus and a chimera of two novel natural viruses. As Davis Relman wrote:
> Some [that's Andersen] have argued that a deliberate engineering scenario is unlikely because one would not have had the insight a priori to design the current pandemic virus. This argument fails to acknowledge the possibility that two or more as yet undisclosed ancestors i.e., more proximal ancestors than RaTG13 and RmYN02) had already been discovered and were being studied in a laboratory—for example, one with the SARS-CoV-2 backbone and spike protein receptor binding domain, and the other with the SARS-CoV-2 polybasic furin cleavage site. It would have been a logical next step to wonder about the properties of a recombinant virus and then create it in the laboratory
https://www.pnas.org/doi/pdf/10.1073/pnas.2021133117 https://www.pnas.org/doi/pdf/10.1073/pnas.2021133117
The WIV had the biggest collection of novel sarbecoviruses in the world.