4 ms·

The argument is not "research accidents categorically do not happen" it was "are they the more common event and therefore the more probable explanation, absent

The argument is not "research accidents categorically do not happen" it was "are they the more common event and therefore the more probable explanation, absent anything else"

tripletao 2y ago
Depending how we count, there have been a dozen or so pandemics comparably novel or deadly to the 1977 flu in the last fifty years. Of those, at least one was research-origin. So are you really saying p ~ 1/12 is an "extraordinary claim"? Is a 6'1" American man "extraordinarily tall"? There's unfortunately no standard map between English phrases and numerical probabilities, but I think most people would understand a much lower probability. If you really want to define it that way, then "extraordinary evidence" is likewise diluted to the point that the circumstantial case (emergence in Wuhan, DEFUSE) brings research origin easily into contention.
- strangecasts 2y ago
  > Depending how we count, there have been a dozen or so pandemics comparably novel or deadly to the 1977 flu in the last fifty years. Of those, at least one was research-origin. So are you really saying p ~ 1/12 is an "extraordinary claim"? Yes, I think it is extraordinary to extrapolate one event in 1977 to a "once every fifty years" rate
  - tripletao 2y ago
    Can you quantify what you believe is a correct prior then, and explain how you got that number? I hope you're not going to count every natural spillover since prehistory in the denominator. The technology to culture and freeze an influenza virus didn't exist before ~1930, and the technology to genetically enhance a sarbecovirus didn't exist before ~2010. The absence of pandemics with such origin before that means nothing. No one had ever suffered a cancer induced by an X-ray tube before 1904; but that doesn't mean the risk wasn't there, and Edison's assistant still died horribly.
    - strangecasts 2y ago
      Apply the same reasoning with the start cutoff at 2010 then
      - tripletao 2y ago
        I said fifty years because that roughly covers the period during which an accident similar to the 1977 flu was possible. Perhaps I should have said longer, since influenza was first cultured in 1931; but we also need some time in the freezer for the circulating virus to diverge. I don't think much changes if we say a hundred years instead. Can you explain why 2010 would be a reasonable start cutoff? That doesn't make any sense to me, since it excludes most of the time that a research-origin flu pandemic was possible. We obviously haven't had a research-origin novel sarbecovirus pandemic before maybe SARS-CoV-2; but when new technological developments occur, the most similar old technologies are our best model. Nobody had ever died in a plane crash before the Wright brothers, but anyone familiar with unpowered gliders could predict the risk.

The argument is not "research accidents categorically do not happen" it was "are they the more common event and therefore the more probable explanation, absent anything else"

tripletao 2y ago

Depending how we count, there have been a dozen or so pandemics comparably novel or deadly to the 1977 flu in the last fifty years. Of those, at least one was research-origin. So are you really saying p ~ 1/12 is an "extraordinary claim"? Is a 6'1" American man "extraordinarily tall"? There's unfortunately no standard map between English phrases and numerical probabilities, but I think most people would understand a much lower probability. If you really want to define it that way, then "extraordinary evidence" is likewise diluted to the point that the circumstantial case (emergence in Wuhan, DEFUSE) brings research origin easily into contention.

strangecasts 2y ago
> Depending how we count, there have been a dozen or so pandemics comparably novel or deadly to the 1977 flu in the last fifty years. Of those, at least one was research-origin. So are you really saying p ~ 1/12 is an "extraordinary claim"? Yes, I think it is extraordinary to extrapolate one event in 1977 to a "once every fifty years" rate
- tripletao 2y ago
  Can you quantify what you believe is a correct prior then, and explain how you got that number? I hope you're not going to count every natural spillover since prehistory in the denominator. The technology to culture and freeze an influenza virus didn't exist before ~1930, and the technology to genetically enhance a sarbecovirus didn't exist before ~2010. The absence of pandemics with such origin before that means nothing. No one had ever suffered a cancer induced by an X-ray tube before 1904; but that doesn't mean the risk wasn't there, and Edison's assistant still died horribly.
  - strangecasts 2y ago
    Apply the same reasoning with the start cutoff at 2010 then
    - tripletao 2y ago
      I said fifty years because that roughly covers the period during which an accident similar to the 1977 flu was possible. Perhaps I should have said longer, since influenza was first cultured in 1931; but we also need some time in the freezer for the circulating virus to diverge. I don't think much changes if we say a hundred years instead. Can you explain why 2010 would be a reasonable start cutoff? That doesn't make any sense to me, since it excludes most of the time that a research-origin flu pandemic was possible. We obviously haven't had a research-origin novel sarbecovirus pandemic before maybe SARS-CoV-2; but when new technological developments occur, the most similar old technologies are our best model. Nobody had ever died in a plane crash before the Wright brothers, but anyone familiar with unpowered gliders could predict the risk.