3 ms·

there's a 19 bp sequence CTCCTCGGCGGGCACGTAG that is directly lifted from the moderna hiv vaccine patent (which preceded covid-19 by a decade). now an exact mat

there's a 19 bp sequence CTCCTCGGCGGGCACGTAG that is directly lifted from the moderna hiv vaccine patent (which preceded covid-19 by a decade). now an exact match of that length isn't impossible, but which is more likely? that this managed to be exactly correct on accident? or some grad student was told to just copypasta every furin cleavage site in the database into a GOF library and surprise surprise the most virulent form that became a pandemic came from the sequence that is engineered to be efficient. any scientist that has any molecular biology wet experience will tell you this is exactly what they would have done (though us researchers would probably not have pulled from the patented BLAST sequences, since that selector is turned off by default by the NCBI)

cyberax 2y ago
> there's a 19 bp sequence CTCCTCGGCGGGCACGTAG that is directly lifted from the moderna hiv vaccine patent Sigh. Here's the first line from the patent: "The present invention provides a cDNA of a severe acute respiratory syndrome (SARS) coronavirus". You don't think that two coronaviruses just might have similar structural proteins?
- ak217 2y ago
  No. The patent in question: https://patents.google.com/patent/US9587003B2/en https://patents.google.com/patent/US9587003B2/en The article: https://www.frontiersin.org/journals/virology/articles/10.3389/fviro.2022.834808/full https://www.frontiersin.org/journals/virology/articles/10.33... The sequence (reverse complemented) matches positions 2751-2733 of sequence ID 11652 attached to the patent: https://seqdata.uspto.gov/seqdetail?docId=US09587003B2&publicationNo=09587003&seqId=11652 https://seqdata.uspto.gov/seqdetail?docId=US09587003B2&publi... - as the other person said, it's located in the S1/S2 furin cleavage site, and produces no BLAST hits outside the SARS-CoV-2 lineage. It's not entirely clear to me when the sequence was incorporated into the patent - it doesn't look like it was in the first revision. But it looks like it was added before 2020. The whole theory still has gaps (even if we assume someone was searching specifically within that patent, what would a screen look like to single out that sequence? It would have to be very high throughput and use very sophisticated modeling), but it's interesting.
  - throwawaymaths 2y ago
    no screen necessary. you create a bunch of dnas by robot building from scratch every FCS known to man. the "screen" is "this is the guy that hapoened jump out of the test tube and cause a pandemic". more of a selection than a screen i guess

cyberax 2y ago

> there's a 19 bp sequence CTCCTCGGCGGGCACGTAG that is directly lifted from the moderna hiv vaccine patent Sigh. Here's the first line from the patent: "The present invention provides a cDNA of a severe acute respiratory syndrome (SARS) coronavirus". You don't think that two coronaviruses just might have similar structural proteins?

ak217 2y ago
No. The patent in question: https://patents.google.com/patent/US9587003B2/en https://patents.google.com/patent/US9587003B2/en The article: https://www.frontiersin.org/journals/virology/articles/10.3389/fviro.2022.834808/full https://www.frontiersin.org/journals/virology/articles/10.33... The sequence (reverse complemented) matches positions 2751-2733 of sequence ID 11652 attached to the patent: https://seqdata.uspto.gov/seqdetail?docId=US09587003B2&publicationNo=09587003&seqId=11652 https://seqdata.uspto.gov/seqdetail?docId=US09587003B2&publi... - as the other person said, it's located in the S1/S2 furin cleavage site, and produces no BLAST hits outside the SARS-CoV-2 lineage. It's not entirely clear to me when the sequence was incorporated into the patent - it doesn't look like it was in the first revision. But it looks like it was added before 2020. The whole theory still has gaps (even if we assume someone was searching specifically within that patent, what would a screen look like to single out that sequence? It would have to be very high throughput and use very sophisticated modeling), but it's interesting.
- throwawaymaths 2y ago
  no screen necessary. you create a bunch of dnas by robot building from scratch every FCS known to man. the "screen" is "this is the guy that hapoened jump out of the test tube and cause a pandemic". more of a selection than a screen i guess