+1 for Salesforce.com. About two years ago I worked on a Salesforce implementation for a political organization. Prior to SF.com, everything lived in Excel spr

+1 for Salesforce.com. About two years ago I worked on a Salesforce implementation for a political organization. Prior to SF.com, everything lived in Excel spreadsheets on network shares. After some research we went all-in on a SF.com implementation. 65 'sales' staff used it (all with 'unlimited' licenses), with between 200-300 users on an in house application at any given time pushing data into SF via the API. Overall, I was quite happy with SF.com. The dashboards and reports are generally quite powerful, and AppExchange is great for hooking into 3rd party apps. If an app isn't available on AppExchange, you can always write custom code and deploy it to SF.com - which we did quite a bit of. SF also has campaign functionality built in - so if you have 250 hot leads you want to work through, you can dump them into a new campaign and just assign calls from that. I recommend getting a SF.com developer account (they're free and you don't need to talk to a salesperson) and trying out some of the functionality. It'll have test data already in there so you can get a feel for how SF envisions you using their product.