If that's what you prefer, there are plenty of options. I'm happy writing Typescript with no framework (or even plain es6), as long as there isn't UI complexity

If that's what you prefer, there are plenty of options. I'm happy writing Typescript with no framework (or even plain es6), as long as there isn't UI complexity. But for a large project, I'll happily trade a compilation step for the tools modern frameworks provide for managing complexity.