Opiates are one thing that really work for depression. Pretty sure that depends on the underlying neurochemical reason for the depression. Norepinephrine and

Opiates are one thing that really work for depression. Pretty sure that depends on the underlying neurochemical reason for the depression. Norepinephrine and Dopamine-related drugs (typically associated with speed) are what helped my depression. One of the tricky things about treatment for mental illness is that things that may appear the same on the surface can vary greatly from person to person as to the root cause (and hence proper treatment).