3 ms·
Maybe a receptor resistance build up? Seems to be a common pattern that medication needs to be dosed up to work- and blunts the receptors for the "normal" amoun
by InDubioProRubio 2y ago
Maybe a receptor resistance build up? Seems to be a common pattern that medication needs to be dosed up to work- and blunts the receptors for the "normal" amount the body produces, if it does not cease to produce it at all.
- AbstractH24 2y agoI'm not quite sure I'm smart enough to follow. Don't sNRIs increase the availability of norepinephrine rather than decrease it? Which is effectively the equivalent of producing more, not less?
- seventytwo 2y agoIn that case, the body would theoretically adjust to down regulate the production of norepinephrine, since there’s already reuptake has been reduced. But… I’m not sure it really works that simply in a real brain.