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> Low doses of fructose are ~90% cleared by the intestine, with only trace fructose but extensive fructose-derived glucose, lactate, and glycerate found in the

> Low doses of fructose are ~90% cleared by the intestine, with only trace fructose but extensive fructose-derived glucose, lactate, and glycerate found in the portal blood. High doses of fructose (≥1 g/kg) overwhelm intestinal fructose absorption and clearance, resulting in fructose reaching both the liver and colonic microbiota. > In many microbes, fructose is phosphorylated on its 6-position and thereby follows nearly the same metabolic pathway as glucose. In mammals, however, fructose phosphorylation occurs on the 1-position, not 6-position, catalyzed by the enzyme ketohexokinase (Khk) (Heinz et al., 1968). The location of this initial phosphorylation is a pivotal difference, as fructose 1-phosphate (F1P) can be directly cleaved into three-carbon units, whereas F6P must be phosphorylated on its 1-position by phosphofructokinase, the most heavily regulated enzyme of glycolysis, before such cleavage. Thus, fructose bypasses the gating step of glycolysis. https://pmc.ncbi.nlm.nih.gov/articles/PMC6032988/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6032988/ "try to find an actual proper double blind academic study that demonstrates a taste difference between sucrose and high fructose corn syrup" are you not able to tell the difference between regular coke and mexican coke?

raverbashing 2y ago
You're just missing the fact that cane sugar has almost the same amount of fructose as HFCS The coke taste difference could be due to HFCS vs table sugar, sure, but it also could be due to some other changes.
- Spooky23 2y ago
  I doubt it. Kosher for passover Coke, made in the US, has a similar taste. It seems weird that they’d make a different product formulation beyond the one that matters (sugar).
llm_nerd 2y ago
The fructose difference is marginal between normal and Mexican coke. In the acidic medium of a cola, sucrose breaks down to glucose and fructose, just as it does with HFCS. HFCS has a bit more fructose, but not enough to make a paper about fructose suddenly relevant. As to the taste difference, Mexican cola has double the sodium. But even then, most people cannot taste the difference. They think they can, proclaim they can, and talk up how great Mexican coke is, but when actually put to the test they have basically random odds of being right or not. Fructose is mostly considered benign if consumed in moderation. You can get fatty liver if you consume to excess, but for most people it has no caloric value and is excreted from the body as a non-nutritive sweetener. Good related video- https://www.youtube.com/watch?v=NY66qpMFOYo https://www.youtube.com/watch?v=NY66qpMFOYo
- DontchaKnowit 2y ago
  They dont taste different to me, but american coke makes my teeth like dry and squeaky, and gives me acid reflux, while latin anerican coke does not. Go figure.
  - pazimzadeh 2y ago
    it is more squeaky, you're right
- pazimzadeh 2y ago
  > most people cannot taste the difference. They think they can, proclaim they can, and talk up how great Mexican coke is, but when actually put to the test they have basically random odds of being right or not Let's set this up. I'm 100% sure I can tell the difference. I grew up in france drinking the sucrose version and I can definitely tell when I'm having a taste of my childhood vs. not. I think what you're trying to say is that you can't tell the difference. Next you'll be telling me that I can't smell the vomit (butyrate) in Hershey's chocolate from the next room over?
  - llm_nerd 2y ago
    [flagged]
    - pazimzadeh 2y ago
      > someone who isn't scientifically ignorant or swayed by Facebook "knowledge" Straw man, I shared an article earlier about fructose skipping a step in the breakdown of glycolysis https://news.ycombinator.com/item?id=42695820 https://news.ycombinator.com/item?id=42695820. These reviews highlight the different effects of fructose and glucose on serum lipids https://pmc.ncbi.nlm.nih.gov/articles/PMC2682989/ https://pmc.ncbi.nlm.nih.gov/articles/PMC2682989/, https://pubmed.ncbi.nlm.nih.gov/8213607/ https://pubmed.ncbi.nlm.nih.gov/8213607/. But yeah I guess I'm just a scientifically ignorant phd With regards to taste, if there are other differences in the formulation Mexican vs US coke then that's another thing, but the difference is definitely noticeable. > they more often than not chose the American coke as the better tasting coke Probably because they grew up with it. People usually like what they are used to. This has to be controlled for. Do the same study with Mexican or European person. > rationally understand they both are just glucose and fructose in a drink like a cola, in slightly different ratios if they are so similar then that's even more impressive, because they definitely taste different. > I have never had Mexican coke, to my knowledge Maybe give it a try, just in case you can taste the difference. By the way, taste is important. Warren Buffett famously described how the taste of Coke doesn't linger in your mouth, making you want to drink "3, 4, 5+ Cokes each day". Can't find the original document right now but here is the excerpt: https://x.com/EugeneNg_VCap/status/1652253327034560532 https://x.com/EugeneNg_VCap/status/1652253327034560532. This is part of the basis of his investment in Coca Cola. It would be interesting to figure out whether this is affected by the choice of sugar.

raverbashing 2y ago

You're just missing the fact that cane sugar has almost the same amount of fructose as HFCS The coke taste difference could be due to HFCS vs table sugar, sure, but it also could be due to some other changes.

Spooky23 2y ago
I doubt it. Kosher for passover Coke, made in the US, has a similar taste. It seems weird that they’d make a different product formulation beyond the one that matters (sugar).

llm_nerd 2y ago

The fructose difference is marginal between normal and Mexican coke. In the acidic medium of a cola, sucrose breaks down to glucose and fructose, just as it does with HFCS. HFCS has a bit more fructose, but not enough to make a paper about fructose suddenly relevant. As to the taste difference, Mexican cola has double the sodium. But even then, most people cannot taste the difference. They think they can, proclaim they can, and talk up how great Mexican coke is, but when actually put to the test they have basically random odds of being right or not. Fructose is mostly considered benign if consumed in moderation. You can get fatty liver if you consume to excess, but for most people it has no caloric value and is excreted from the body as a non-nutritive sweetener. Good related video- https://www.youtube.com/watch?v=NY66qpMFOYo https://www.youtube.com/watch?v=NY66qpMFOYo

DontchaKnowit 2y ago
They dont taste different to me, but american coke makes my teeth like dry and squeaky, and gives me acid reflux, while latin anerican coke does not. Go figure.
- pazimzadeh 2y ago
  it is more squeaky, you're right
pazimzadeh 2y ago
> most people cannot taste the difference. They think they can, proclaim they can, and talk up how great Mexican coke is, but when actually put to the test they have basically random odds of being right or not Let's set this up. I'm 100% sure I can tell the difference. I grew up in france drinking the sucrose version and I can definitely tell when I'm having a taste of my childhood vs. not. I think what you're trying to say is that you can't tell the difference. Next you'll be telling me that I can't smell the vomit (butyrate) in Hershey's chocolate from the next room over?
- llm_nerd 2y ago
  [flagged]
  - pazimzadeh 2y ago
    > someone who isn't scientifically ignorant or swayed by Facebook "knowledge" Straw man, I shared an article earlier about fructose skipping a step in the breakdown of glycolysis https://news.ycombinator.com/item?id=42695820 https://news.ycombinator.com/item?id=42695820. These reviews highlight the different effects of fructose and glucose on serum lipids https://pmc.ncbi.nlm.nih.gov/articles/PMC2682989/ https://pmc.ncbi.nlm.nih.gov/articles/PMC2682989/, https://pubmed.ncbi.nlm.nih.gov/8213607/ https://pubmed.ncbi.nlm.nih.gov/8213607/. But yeah I guess I'm just a scientifically ignorant phd With regards to taste, if there are other differences in the formulation Mexican vs US coke then that's another thing, but the difference is definitely noticeable. > they more often than not chose the American coke as the better tasting coke Probably because they grew up with it. People usually like what they are used to. This has to be controlled for. Do the same study with Mexican or European person. > rationally understand they both are just glucose and fructose in a drink like a cola, in slightly different ratios if they are so similar then that's even more impressive, because they definitely taste different. > I have never had Mexican coke, to my knowledge Maybe give it a try, just in case you can taste the difference. By the way, taste is important. Warren Buffett famously described how the taste of Coke doesn't linger in your mouth, making you want to drink "3, 4, 5+ Cokes each day". Can't find the original document right now but here is the excerpt: https://x.com/EugeneNg_VCap/status/1652253327034560532 https://x.com/EugeneNg_VCap/status/1652253327034560532. This is part of the basis of his investment in Coca Cola. It would be interesting to figure out whether this is affected by the choice of sugar.